Immunostimulatory DNA reverses established allergen-induced airway remodeling.

Airway Hyperreactivity in a Murine Asthma Protects Against, and Reverses Established, Vaccination with Allergen-IL-18 Fusion DNA

Allergen-Induced Airway Hyperreactivity the Development of and Reverses Established IL-18 Gene Transfer by Adenovirus Prevents

Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade.

RATIONALE Airway inflammation in asthma is accompanied by structural changes, including goblet cell metaplasia, smooth muscle cell layer thickening, and subepithelial fibrosis. This allergen-induced airway remodeling can be replicated in a mouse asthma model. OBJECTIVES The study goal was to determine whether established airway remodeling in a mouse asthma model is reversible by administratio...

Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice.

We have used a mouse model of allergen-induced airway hyperresponsiveness to demonstrate that immunostimulatory DNA sequences (ISS) containing a CpG DNA motif significantly inhibit airway eosinophilia and reduce responsiveness to inhaled methacholine. ISS not only inhibited eosinophilia of the airway (by 93%) and lung parenchyma (91%), but also significantly inhibited blood eosinophilia (86%), ...

Regional differences in the pattern of airway remodeling following chronic allergen exposure in mice

BACKGROUND Airway remodeling present in the large airways in asthma or asthma models has been associated with airway dysfunction in humans and mice. It is not clear if airways distal to the large conducting airways have similar degrees of airway remodeling following chronic allergen exposure in mice. Our objective was to test the hypothesis that airway remodeling is heterogeneous by optimizing ...